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PredDimer

PredDimer is an algorithm to predict heterodimeric protein complexes with pairwise kernel function and Support Vector Machines (SVM). Please read paper Improving prediction of heterodimeric protein complexes using combination with pairwise kernel for details.

Getting Started

These instructions will get you a copy of the project up and running on your local machine for development and testing purposes.

Prerequisites

What things you need to install the software and how to install them

Environment

  • Library: libsvm-3.0.2
  • Programming language: C++

Data

  • cyc2008.data - downloaded from cyc2008
  • pro200600448_3_s.csv - downloaded from WI-PHI
  • uniprot_sprot_fungi.dat - downloaded from UniProtKB

Usage

g++ pairwise-kernel.cpp -o dimer
./dimer 1 2 3 4 5 8 9 a filename1.txt filename2.txt
./svm-train -q -t 4 -v 10 -w1 b -w-1 c filename2.txt

a: b: weight of positive examples c: weight of negative examples

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